Serotonin reuptake inhibitors SRIs are widely used for the treatment of psychiatric disorders, including obsessive-compulsive disorder OCD. SRIs commonly cause delayed orgasm, the mechanism of which is poorly understood. Oxytocin is involved in sexual function and is interconnected with serotonin within the brain. SRIs are reported to affect the oxytocin system, but possible relations between SRI-induced changes of sexual function and oxytocin are unexplored in humans. In a randomized, double-blinded, placebo-controlled trial of OCD, the anti-obsessive efficacy and adverse events of SRIs and oxytocin measurements were studied. Reported sexual function and oxytocin plasma levels at rest were studied in 31 adults 15 men and 16 women with OCD who participated in a randomized, double-blinded trial comparing the SRIs clomipramine and paroxetine with placebo. Sexual adverse effects were quantified by a clinician-administered semistructured interview.
The first, definitive text on female sexual dysfunction, this major new book summarizes the current body of knowledge in the field, traces the history of developments in the area, and identifies work still needed in the future. Reflecting a multidisciplinary approach to the subject, the book details the methods and materials for ensuring the appropriate management of women with sexual health problems, and concentrates on the presentation of evidence-based data concerning the physiology, pathophysiology, diagnosis and treatment of sexual function and dysfunction in women. The inclusion of 'difficult cases' also enhances the use of text as a practical guide to all disciplines concerned with the field of female sexual dysfunction. This important work will become a key resource for basic science researchers, endocrinologists, gynecologists, psychologists, urologists, health care clinicians, and anyone else interested in women's sexual health.
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